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KMID : 1161420210240080841
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Journal of Medicinal Food
2021 Volume.24 No. 8 p.841 ~ p.851
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High-Fat Diet with Lyophilized Acrocomia aculeata Pulp Increases High-Density Lipoprotein-Cholesterol Levels and Inhibits Adipocyte Hypertrophy in Mice
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Fernandes Melina Ribeiro
Rezende Karoline Silva
Inada Aline Carla
de Cassia Freitas Karine
de Oliveira Filiu Wander Fernando
Cavalheiro Leandro Fontoura
Nazario Carlos Eduardo Domingues
Hiane Priscila Aiko
Croda Julio
Tatara Mariana Bento
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Abstract
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Obesity is a relevant health hazard characterized as a chronic noncommunicable disease, with severe comorbidities that cause mortality worldwide. Acrocomia aculeata is a Brazilian palm with edible fruits. Its pulp contains fibers, monounsaturated fatty acids (MUFAs), such as oleic acid and carotenoids. In this context, our study aimed to elucidate the protective effect of the lyophilized A. aculeata pulp added at the rates of 1%, 2%, and 4% to a high-fat (HF) diet (rich in saturated fats and cholesterol), for 90 days, in mice. The treatment with 4% pulp induced a significant increase in the biochemical parameters of serum cholesterol HDL-C (high-density lipoprotein) compared with the control. According to the evaluation of the epididymal tissue, the groups treated with A. aculeata pulp exhibited smaller fat deposits compared with the HF diet group. Therefore, we infer that the predominant components in A. aculeata, particularly fibers and MUFAs, promote beneficial effects on health parameters during simultaneous exposure to food rich in saturated fat and cholesterol, typical of the Western diet. This is the first study to correlate the presence of fatty acids from A. aculeata pulp in different proportions added in a HF diet with metabolic and histological parameters in Swiss mice.
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KEYWORD
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chronic noncommunicable diseases, dietary lipids, monounsaturated fatty acids, obesity
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